HCID 69044992、化合物 → HCID 69043464、化合物
反応式
[O:1]=[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([CH2:12][CH:13]2[CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15][N:14]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[N:4][NH:3]1>O1CCCC1.[Pd]>[O:1]=[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([CH2:12][CH:13]2[CH2:18][NH:17][CH2:16][CH2:15][N:14]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[N:4][NH:3]1参加物
4
実験手順
A solution of EXAMPLE 257D (0.77 g, 1.6 mmol) in tetrahydrofuran (100 ml) was treated with 10% palladium on carbon (85 mg, 0.8 mmol) at room temperature under hydrogen (balloon) overnight. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by flash chromatography (0-15% gradient of methanol in CH2Cl2) to provide the title compound. MS (DCI/NH3) m/z 349 (M+H)+.
後処理
- custom