N-bromobutanimide → HCID 58355460、化合物

HRID 1260046ノート

反応式

HRID 1260046 の反応式
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[C:8]1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[Br:17]N1C(=O)CCC1=O>C(#N)C>[Br:17][C:10]1[N:9]=[C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:7]([CH2:6][CH2:5][CH2:4][CH2:3][O:2][CH3:1])[CH:11]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 58355716HCID 58355716、化合物

生成物 1

HCID 58355460HCID 58355460、化合物収率 23.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

Ethyl 1-(4-methoxybutyl)-1H-imidazole-2-carboxylate (2.18 g) was dissolved in acetonitrile (30 ml), N-bromosuccinimide (1.71 g) was added and the mixture was stirred at 60° C. for 14 hr. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, and a fraction eluted with ethyl acetate-hexane (10:90-70:30) was concentrated under reduced pressure to give the object product (689 mg).

後処理

  1. temperatureAfter cooling to room temperature
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. washa fraction eluted with ethyl acetate-hexane (10:90-70:30)
  4. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-45b7a1ff15b947db8e7af4a06984df10
出典データセット
uspto-grants-2013_06
特許番号
US08466282B2

反応ノート

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