Lithium Hydroxide → Methylsuccinic acid

HRID 1260407

反応式

HRID 1260407 の反応式
[CH3:1][CH:2]([CH2:7][C:8]([O:10]C)=[O:9])[C:3]([O:5]C)=[O:4].[OH-].[Li+]>O1CCCC1.O>[CH3:1][CH:2]([CH2:7][C:8]([OH:10])=[O:9])[C:3]([OH:5])=[O:4]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 15350Butanedioic acid, 2-methyl-, 1,4-dimethyl ester

生成物 1

HCID 10349Methylsuccinic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
40 °C

実験手順

Commercially available dimethyl methylsuccinate (1.57 g, 9.8 mmol) was dissolved in a 3:1 mixed solvent of tetrahydrofuran and water, and lithium hydroxide (4 g, 98 mmol) was added and stirred for 2 days at 40° C. under reflux. After completion of the reaction was confirmed by TLC, the residue was distilled under reduced pressure to afford the title compound.

後処理

  1. additionwas added
  2. temperatureunder reflux
  3. distillationthe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-5c1c95c30a16424cb4d6a70811034722
出典データセット
uspto-grants-2013_06
特許番号
US08470836B2

関連ノート

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