Sulfuryl chloride → 1-Propanone, 2-chloro-2-methyl-1-phenyl-

HRID 1266673

反応式

HRID 1266673 の反応式
[C:1]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].S(Cl)([Cl:15])(=O)=O>CCCCCCC>[Cl:15][C:2]([CH3:4])([CH3:3])[C:1]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 69144Isobutyrophenone

生成物 1

HCID 819851-Propanone, 2-chloro-2-methyl-1-phenyl-

試薬・触媒・溶媒 1

HCID 8900Heptane溶媒

実験手順

Isobutyrophenone (30.0 g, 0.20 mole) was dissolved in heptane (10 ml) and sulfuryl chloride (35 g, 0.26 mole) was added at once. After a few minutes gas evolution occurred. After 3 h of stirring at room temperature the reaction mixture was concentrated. The concentrate was dissolved in heptane (250 ml) and washed with 150 ml of an aqueous 2 wt % sodium bicarbonate solution. After drying over magnesium sulfate the solvent was removed under reduced pressure. The yield of 2-chloro-2-methylpropiophenone was 36.4 g or 98%.

後処理

  1. waitAfter a few minutes gas evolution occurred
  2. concentrationwas concentrated
  3. dissolutionThe concentrate was dissolved in heptane (250 ml)
  4. washwashed with 150 ml of an aqueous 2 wt % sodium bicarbonate solution
  5. dry with materialAfter drying over magnesium sulfate the solvent
  6. customwas removed under reduced pressure

出典と根拠

ORDレコード
ord-a07e5f5e6b3a40f2bc70bf1e69f1195a
出典データセット
uspto-grants-2003_04
特許番号
US06548710B2

関連ノート

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