Hydrochloric Acid → HCID 15114475、化合物

HRID 126674ノート

反応式

HRID 126674 の反応式
O[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][CH2:4][NH:5][CH3:6].Cl.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][CH2:4][NH:5][CH3:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 27339893-Methylamino-1-phenylpropanol

生成物 1

HCID 15114475HCID 15114475、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a cooled suspension of 20 g of γ-hydroxy-N-methylphenylpropylamine.HCl in chloroform are added dropwise 30 ml of thionylchloride. The mixture is subsequently stirred at room temperature till all solid substance has been dissolved. The solvent chloroform and the excess of thionylchloride are distilled off after which the residue is washed with ether and then made alkaline (pH=8) with a sodiumcarbonate solution (10%). The alkaline solution is subsequently extracted with ether and the ether extracts washed with water, dried and evaporated to dryness. The residue (oil) is used without any additional purification (yield 15.6 g; 85%).

後処理

  1. dissolutionhas been dissolved
  2. distillationThe solvent chloroform and the excess of thionylchloride are distilled off after which the residue
  3. washis washed with ether
  4. extractionThe alkaline solution is subsequently extracted with ether
  5. washthe ether extracts washed with water
  6. customdried
  7. customevaporated to dryness
  8. customThe residue (oil) is used without any additional purification (yield 15.6 g; 85%)

出典と根拠

ORDレコード
ord-370890994df44bb58148c361ceeb5f62
出典データセット
uspto-grants-1981_03
特許番号
US04254031

反応ノート

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