Ethylene Glycol → 2-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

HRID 126736ノート

反応式

HRID 126736 の反応式
[OH:1][CH2:2][C:3](=[O:16])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[C:11](=[O:15])[CH2:12][CH2:13][CH:14]=1.[CH2:17](O)[CH2:18][OH:19].CC1C=CC(S(O)(=O)=O)=CC=1.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[CH2:18]1[O:19][C:11]2([CH2:12][CH2:13][CH:14]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3](=[O:16])[CH2:2][OH:1])[O:15][CH2:17]1

参加物

6

反応物 4

HCID 174Ethylene GlycolHCID 6101p-Toluenesulfonic acidHCID 516892Sodium BicarbonateHCID 202876282-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one

生成物 1

HCID 867375372-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 5.5 g. of 2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one (Example 88), 25 ml. of ethylene glycol, and 0.1 g. of P-toluenesulfonic acid in 200 ml. of toluene is reflucted for 40 minutes using a Dean-Stark trap. The solution is poured into saturated sodium bicarbonate. The mixture is extracted with benzene. The organic solution is washed three times with water and dried over magnesium sulfate. The solvent is removed to give 6.0 g. of the title compound.

後処理

  1. extractionThe mixture is extracted with benzene
  2. washThe organic solution is washed three times with water
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent is removed
  5. customto give 6.0 g

出典と根拠

ORDレコード
ord-f49fcb853420467cba341134c29cc80e
出典データセット
uspto-grants-1981_03
特許番号
US04254036

反応ノート

読み込み中…