Chloroform → N-(7-ethoxy-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

HRID 126892ノート

反応式

HRID 126892 の反応式
[OH:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH2:7][CH2:8][CH:9]([NH:15][C:16](=[O:18])[CH3:17])[CH2:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1.[CH2:19](I)[CH3:20].C([O-])([O-])=O.[K+].[K+].C(Cl)(Cl)Cl>O>[CH2:19]([O:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH2:7][CH2:8][CH:9]([NH:15][C:16](=[O:18])[CH3:17])[CH2:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1)[CH3:20]

参加物

6

反応物 4

HCID 6212ChloroformHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 20529233N-(1,3,4,9-tetrahydro-7-hydroxy-2H-carbazol-2-yl)acetamide

生成物 1

HCID 20529245N-(7-ethoxy-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 0.02 mol of N-(1,3,4,9-tetrahydro-7-hydroxy-2H-carbazol-2-yl)acetamide, 0.022 mol of ethyl iodide, 0.022 mol of anhydrous K2CO3, and 50 ml of Me2CO was stirred and refluxed for 48 hr. Sufficient CHCl3 and H2O were added to the cooled reaction mixture to give two clear layers. The CHCl3 layer was washed with 1 N NaOH, H2O, dried, evaporated, and the resulting solid residue was recrystallized from i-PrOH to give the title compound, mp 184°-186°.

後処理

  1. temperaturerefluxed for 48 hr
  2. customto give two clear layers
  3. washThe CHCl3 layer was washed with 1 N NaOH, H2O
  4. customdried
  5. customevaporated
  6. customthe resulting solid residue was recrystallized from i-PrOH

出典と根拠

ORDレコード
ord-9c73945c65274a80b3d8e1aaa760b5f1
出典データセット
uspto-grants-1981_03
特許番号
US04254134

反応ノート

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