反応式
S(O)(O)(=O)=O.[CH3:6][O:7][C:8](=[NH:10])[NH2:9].[CH3:11][O:12][C:13](Cl)=[O:14].[OH-].[Na+]>O>[CH3:11][O:12][C:13]([NH:10][C:8](=[NH:9])[O:7][CH3:6])=[O:14]参加物
5
実験手順
246 g of O-methylisourea sulfate are dissolved in 300 ml of water and 163 ml of chloroformic acid methyl ester are added dropwise at 10° C., followed by 170 g of NaOH, dissolved in 510 ml of water. The mixture is stirred at room temperature for a further 3 hours. The reaction solution is then extracted with ethyl acetate and this extract is dried with anhydrous sodium sulfate. Evaporation under reduced pressure at a maximum bath temperature of 40° C. gives the N-methoxycarbonyl-O-methylisourea as an oil, which gradually solidifies to form crystals with a melting point of 40° C. Yield 150 g.
後処理
- extractionThe reaction solution is then extracted with ethyl acetate
- dry with materialthis extract is dried with anhydrous sodium sulfate
- customEvaporation under reduced pressure at a maximum bath temperature of 40° C.
出典と根拠
- ORDレコード
- ord-6b9117b65bf24eb2a443470fd78e9f40
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04254143
関連ノート
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