N-bromobutanimide → 1H-Indazol-5-ol,4-broMo-

HRID 1269919ノート

反応式

HRID 1269919 の反応式
[Br:1]N1C(=O)CCC1=O.[NH:9]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[CH:11]=[N:10]1>O1CCCC1>[Br:1][C:13]1[C:14]([OH:18])=[CH:15][CH:16]=[C:17]2[C:12]=1[CH:11]=[N:10][NH:9]2

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 1014381H-Indazol-5-ol

生成物 1

HCID 229341081H-Indazol-5-ol,4-broMo-収率 91%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

N-bromosuccinimide (1.06 g, 5.96 mmol) was added to a solution of the 1H-indazol-5-ol (800 mg, 5.96 mmol) obtained in Reference Example 4 in tetrahydrofuran (20 ml) at room temperature. The resulting mixture was stirred for 14 hours while being maintained at room temperature. The mixture was concentrated under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate) to obtain 4-bromo-1H-indazol-5-ol (1.15 g, 91%).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-71418cc7433644339b4d46e5fc3fbccc
出典データセット
uspto-grants-2007_04
特許番号
US07199147B2

反応ノート

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