Water → 2-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide

HRID 1270098ノート

反応式

HRID 1270098 の反応式
N1C=CC=CC=1.[NH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[C:9]=1[OH:15].[Br:16][C:17]([CH3:22])([CH3:21])[C:18](Br)=[O:19].O>C(Cl)Cl>[Br:16][C:17]([CH3:22])([CH3:21])[C:18]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[C:9]=1[OH:15])=[O:19]

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 886852-Bromo-2-methylpropionyl bromideHCID 155315062-Amino-6-bromophenol

生成物 1

HCID 218735182-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Pyridine (1.8 ml, 22.3 mmol) was added to a solution of 2-amino-6-bromo-phenol (4.198 g, 22.3 mmol) in dry CH2Cl2 (200 ml). The mixture was cooled in ice and then a solution of 2-bromo-2-methyl-propionylbromide (2.8 ml, 22.6 mmol) was added slowly. The mixture was stirred at the room temperature for an hour and was poured into CH2Cl2. and water. The organic layer was washed with water, dried and concentrated in vacuo to yield crude 2-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide, which was used directly in step 2 without further purification.

後処理

  1. temperatureThe mixture was cooled in ice
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2e7b3b9902d947de8c2f47c251c6b96c
出典データセット
uspto-grants-2007_04
特許番号
US07202241B2

反応ノート

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