N-bromobutanimide → 4-Bromo-3,5-difluoroaniline

HRID 1270728

反応式

HRID 1270728 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].C1C(=O)N([Br:17])C(=O)C1>CN(C=O)C.CCOCC>[Br:17][C:8]1[C:2]([F:1])=[CH:3][C:4]([NH2:5])=[CH:6][C:7]=1[F:9]

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 965953,5-Difluoroaniline

生成物 1

HCID 27362604-Bromo-3,5-difluoroaniline

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

3,5-Difluoroaniline (10.0 g, 77.5 mmol) is dissolved in DMF (100 mL). NBS (13.9 g, 78.0 mmol) is added portionwise at room temperature. After stirring overnight at room temperature, the reaction mixture is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil which is purified by column chromatography (methylene chloride/hexanes) to give 4-bromo-3,5-difluoroaniline.

後処理

  1. washwashed with brine
  2. dry with materialThe separated organic phase is dried (Na2SO4)
  3. concentrationconcentrated
  4. customto give an oil which
  5. customis purified by column chromatography (methylene chloride/hexanes)

出典と根拠

ORDレコード
ord-e552a0d6f13146c99cc37f51be6c777b
出典データセット
uspto-grants-2007_04
特許番号
US07202364B2

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