Sodium Hydroxide → Tert-butyl 4-(trifluoromethoxy)phenylcarbamate

HRID 1270788ノート

反応式

HRID 1270788 の反応式
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1.[C:13](=O)([O:19]C(C)(C)C)[O:14][C:15]([CH3:18])([CH3:17])[CH3:16].[OH-].[Na+]>C1COCC1>[C:13]([NH:8][C:7]1[CH:9]=[CH:10][C:4]([O:3][C:2]([F:11])([F:12])[F:1])=[CH:5][CH:6]=1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:19]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 6008484-(Trifluoromethoxy)anilineHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) ester

生成物 1

HCID 11196668Tert-butyl 4-(trifluoromethoxy)phenylcarbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4-Trifluoromethoxyaniline (100 g, 0.58 mol), di-tert-butyl carbonate (127 g, 0.58 mol) and 1 N NaOH solution (250 mL) are dissolved in THF (200 mL) and stirred at room temperature for 12 hours. The reaction mixture is extracted with EtOAc (500 mL). The organic layer is washed with 1 N HCl (500 mL), brine (250 mL) and dried (MgSO4). The solvent is removed by rotary evaporator to give N-BOC-4-trifluoromethoxyaniline.

後処理

  1. extractionThe reaction mixture is extracted with EtOAc (500 mL)
  2. washThe organic layer is washed with 1 N HCl (500 mL), brine (250 mL)
  3. dry with materialdried (MgSO4)
  4. customThe solvent is removed by rotary evaporator

出典と根拠

ORDレコード
ord-5b342cadb8244c19a82371722e2f902c
出典データセット
uspto-grants-2007_04
特許番号
US07202364B2

反応ノート

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