1-[3-(4-nitro-phenoxy)-propyl]-1H-[1,2,3]triazole → 4-(3-[1,2,3]Triazol-1-yl-propoxy)-phenylamine

HRID 1271413ノート

反応式

HRID 1271413 の反応式
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:6][CH:5]=1)([O-])=O>C1COCC1.[Pd]>[N:12]1([CH2:11][CH2:10][CH2:9][O:8][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:18][CH:17]=2)[CH:16]=[CH:15][N:14]=[N:13]1

参加物

4

反応物 1

HCID 184535181-[3-(4-nitro-phenoxy)-propyl]-1H-[1,2,3]triazole

生成物 1

HCID 184535284-(3-[1,2,3]Triazol-1-yl-propoxy)-phenylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

1-[3-(4-Nitro-phenoxy)-propyl]-1H-[1,2,3]triazole (2.87 g, 11.6 mmol) is dissolved in THF (40 ml) and hydrogenated for 2.5 h in the presence of palladium on charcoal (10%, 500 mg). After filtration and concentration in vacuo 4-(3-[1,2,3]Triazol-1-yl-propoxy)-phenylamine can be isolated as orange oil which is precipitated with diethyl ether. Yield 2.48 g (98%)

後処理

  1. filtrationAfter filtration and concentration in vacuo 4-(3-[1,2,3]Triazol-1-yl-propoxy)-phenylamine
  2. customcan be isolated as orange oil which
  3. customis precipitated with diethyl ether

出典と根拠

ORDレコード
ord-a2fd757ed50d42b790a80a504b568d8a
出典データセット
uspto-grants-2007_04
特許番号
US07205326B2

反応ノート

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