Hydrochloric Acid → HCID 12876160、化合物

HRID 127293

反応式

HRID 127293 の反応式
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].[C:14](Cl)(=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16].Cl>[OH-].[Na+]>[C:14]([S:8][CH2:7][C@@H:6]([C:9]([OH:11])=[O:10])[NH:5][C:3](=[O:4])[C:2]([S:1][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:12])(=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 62493Pivaloyl chlorideHCID 656604Bucillamine

生成物 1

HCID 12876160HCID 12876160、化合物収率 16.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒2 回

実験手順

N-(2-Mercapto-2-methylpropanoyl)-L-cysteine (11.2 g, 0.05 mol) is dissolved in N sodium hydroxide (50 ml) and pivaloyl chloride (17.0 g, 0.13 mol) and aqueous N sodium hydroxide (150 ml) are added dropwise at 0° C. with stirring under a nitrogen atmosphere. After the addition, the mixture is stirred for 1 hour at room temperature and acidified with 6 N hydrochloric acid. The produced oil is extracted with ethyl acetate and the organic layer is washed with water, dried and concentrated to dryness under reduced pressure to yield 3.2 g (16.4%) of S-pivaloyl-N-(S-pivaloyl-2-mercapto-2-methylpropanoyl)-L-cysteine.

後処理

  1. additionare added dropwise at 0° C.
  2. additionAfter the addition
  3. stirringthe mixture is stirred for 1 hour at room temperature
  4. extractionThe produced oil is extracted with ethyl acetate
  5. washthe organic layer is washed with water
  6. customdried
  7. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-7c4dd1599f7b4ac3a70bf509b882be75
出典データセット
uspto-grants-1981_03
特許番号
US04255446

関連ノート

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