Chloroacetic Acid → HCID 12876168、化合物

HRID 127295

反応式

HRID 127295 の反応式
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].Cl[CH2:15][C:16]([OH:18])=[O:17].[I-].[K+].Cl.[Cl-].[Na+]>C(=O)([O-])[O-].[K+].[K+]>[C:16]([CH2:15][S:8][CH2:7][C@@H:6]([C:9]([OH:11])=[O:10])[NH:5][C:3](=[O:4])[C:2]([S:1][CH2:6][C:9]([OH:11])=[O:10])([CH3:13])[CH3:12])([OH:18])=[O:17]

参加物

7

反応物 5

HCID 300Chloroacetic AcidHCID 313Hydrochloric AcidHCID 4875Potassium IodideHCID 5234Sodium ChlorideHCID 656604Bucillamine

生成物 1

HCID 12876168HCID 12876168、化合物収率 194.5%

試薬・触媒・溶媒 1

HCID 11430Potassium Carbonate溶媒

実験手順

N-(2-Mercapto-2-methylpropanoyl)-L-cysteine (11.2 g, 0.05 mol) is dissolved in 1 M potassium carbonate and monochloroacetic acid (11.3 g, 0.12 mol) and potassium iodide (1.0 g) are added. The mixture is stirred overnight at room temperature under a nitrogen atmosphere and acidified with 6 N hydrochloric acid. Sodium chloride is added and the mixture is extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride solution, dried and concentrated to dryness to yield 16.5 g (97.2%) of S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine.

後処理

  1. extractionthe mixture is extracted with ethyl acetate
  2. washThe organic layer is washed with saturated sodium chloride solution
  3. customdried
  4. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-44272a91e41947378530daad8def6fc9
出典データセット
uspto-grants-1981_03
特許番号
US04255446

関連ノート

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