Water → 1,2,3,5,6,8a-Hexahydroindolizine-7-methanol
反応式
[CH2:1]1[CH:9]2[N:4]([CH2:5][CH2:6][C:7]([C:10](OCC)=[O:11])=[CH:8]2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>C1COCC1>[CH2:1]1[CH:9]2[N:4]([CH2:5][CH2:6][C:7]([CH2:10][OH:11])=[CH:8]2)[CH2:3][CH2:2]1参加物
6
実験手順
Ethyl 1,2,3,5,6,8a-hexahydroindolizine-7-carboxylate (D1, 0.89 g, 4.6 mmol) was stirred under Ar in dry THF (50 ml) as lithium aluminium hydride (0.35 g, 9.2 mmol) was added portionwise. After 30 min, the reaction was worked up by successive addition of water (0.35 ml), 10% NaOH (0.35 ml) and water (1.05 ml). The solid was filtered off, and the filtrate was evaporated to yield the title compound (0.67 g, 97%) as a brown oil.
後処理
- additionwas added portionwise
- filtrationThe solid was filtered off
- customthe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-84bee37117a24bd39308a70e372cb6f6
- 出典データセット
- uspto-grants-2000_12
- 特許番号
- US06156783
反応ノート
読み込み中…