Water → (1R,2S)-(+)-cis-1-Amino-2-indanol

HRID 1274435

反応式

HRID 1274435 の反応式
[C@@H:1]1(O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[OH:10].S(=O)(=O)(O)O.O.[OH-].[Na+].C(#[N:22])C>>[NH2:22][C@@H:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10]

参加物

6

反応物 5

HCID 962WaterHCID 1118Sulfuric AcidHCID 6342AcetonitrileHCID 14798Sodium HydroxideHCID 247603trans-1,2-Indandiol

生成物 1

HCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanol

反応条件

温度
0 °C

実験手順

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol.

後処理

  1. temperatureThe mixture was gradually warmed to 20° C. and aged to 3 hours
  2. temperaturethe mixture heated to reflux
  3. customThe resulting solid was removed by filtration

出典と根拠

ORDレコード
ord-faeba2f9f1af40cda6eb775fa83d49a1
出典データセット
uspto-grants-2000_12
特許番号
US06156895

関連ノート

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