反応式
[CH2:1]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][OH:13])[CH:7]=1)[CH2:2][CH2:3][CH3:4].N1C=CC=CC=1.[Br:20][CH2:21][C:22](Br)=[O:23].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[CH2:1]([N:5]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][OH:13])[CH:7]=1)[C:22](=[O:23])[CH2:21][Br:20])[CH2:2][CH2:3][CH3:4]参加物
6
反応条件
- 温度
- 0 °C
実験手順
To a solution of 3.42 g (19.2 mmol) of the compound of Example 532A in 20 ml toluene, was added 2.42 ml (30 mmol) pyridine. The mixture was cooled to 0° C.; 4.025 gm (20.0 mmol) of bromoacetyl bromide (diluted with 5 ml toluene) was added in a dropwise fashion. The reaction mixture was allowed to stir for 5 hours at 0° C. and then was allowed to warm to room temperature. Saturated potassium carbonate solution was added, and the mixture was stirred vigorously for 2 hours. The mixture was extracted with EtOAc; the organic layer was washed with 1N H3PO4, water, and brine.
後処理
- temperatureto warm to room temperature
- stirringthe mixture was stirred vigorously for 2 hours
- extractionThe mixture was extracted with EtOAc
- washthe organic layer was washed with 1N H3PO4, water, and brine
出典と根拠
- ORDレコード
- ord-a12f475ab6d6437bb1d940f32dd67f4f
- 出典データセット
- uspto-grants-2000_12
- 特許番号
- US06162927
関連ノート
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