Benzyl Bromide → 1-(Phenylmethyl)-1H-1,2,4-triazole

HRID 127660

反応式

HRID 127660 の反応式
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[N:12][CH:11]=[N:10]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([N:9]1[CH:13]=[N:12][CH:11]=[N:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 92571H-1,2,4-TriazoleHCID 11430Potassium Carbonate

生成物 1

HCID 224581-(Phenylmethyl)-1H-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 34.2 parts by weight of benzyl bromide, 13.8 parts by weight of 1,2,4-triazole and 41.4 parts by weight of potassium carbonate in 150 parts by weight of acetonitrile is refluxed for 10 hours while stirring. The mixture is filtered and the filtrate is evaporated to dryness and recrystallized from a mixture of toluene and cyclohexane. There is obtained 21 parts by weight of 1-benzyl-1,2,4-triazole; m.p.: 58° C.

後処理

  1. temperatureis refluxed for 10 hours
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated to dryness
  4. customrecrystallized from a mixture of toluene and cyclohexane

出典と根拠

ORDレコード
ord-26e929fcdfca4b17826444a9104df6a9
出典データセット
uspto-grants-1981_03
特許番号
US04256754

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