Hydrochloric Acid → 5,8-Dichloroimidazo-[1,2-a]-quinoline-2-carboxylic acid

HRID 1277967ノート

反応式

HRID 1277967 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]2[CH:13]=[C:14]([C:16]([O:18]CC)=[O:17])[N:15]=[C:4]2[CH:3]=1.[OH-].[Na+].C(COC)OC.Cl>C(O)C>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]2[CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=[C:4]2[CH:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 80711,2-DimethoxyethaneHCID 14798Sodium HydroxideHCID 12763976Ethyl 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylate

生成物 1

HCID 127639755,8-Dichloroimidazo-[1,2-a]-quinoline-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.24 g of ethyl 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylate were hydrolyzed with 3 ml of 2 N sodium hydroxide solution in 120 ml of 50--50 mixture of dimethoxyethane and ethanol. The resultant mixture was neutralized with 3.3 ml of 2 N hydrochloric acid by the method of Example 20 to obtain fine off-white crystals of 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylic acid melting at ≈305° C. (decomp).

出典と根拠

ORDレコード
ord-f123739e905c4db1a170cb8e0e6028e8
出典データセット
uspto-grants-1981_07
特許番号
US04279912

反応ノート

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