Sodium Hydroxide → 2-(4-Bromobenzyl)-1-methylpyrrolidine
反応式
[Br:1]Br.[CH2:3]([CH:10]1[CH2:14][CH2:13][CH2:12][N:11]1[CH3:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+]>[Fe]>[Br:1][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH3:15])=[CH:5][CH:6]=1参加物
5
実験手順
Add 11.4 moles of bromine at room temperature to 2 g of 2-benzyl-1-methylpyrrolidine and 50 mg of iron powder. Allow the resulting mixture to stand for 2 hours before rendering it alkaline 1 N sodium hydroxide solution. Extract the base with diethyl ether. Distil the ether extract to obtain the title compound as almost-colorless liquid of b.p. 72° at 0.001 mm of Hg.
後処理
- extractionExtract the base with diethyl ether
- customDistil the ether
- extractionextract
出典と根拠
- ORDレコード
- ord-ae3e686b01884283883d52e184233057
- 出典データセット
- uspto-grants-1981_07
- 特許番号
- US04279918
反応ノート
読み込み中…