Hexadecanolide → 16-Iodohexadecanoic acid

HRID 1279134

反応式

HRID 1279134 の反応式
[C:1]1(=[O:18])[O:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[IH:19].S([O-])([O-])(=O)=S.[Na+].[Na+]>C(O)(=O)C>[I:19][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([OH:17])=[O:18]

参加物

5

反応物 3

HCID 7984HexadecanolideHCID 24477Sodium ThiosulfateHCID 24841Hydrogen iodide

生成物 1

HCID 4111116-Iodohexadecanoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
100 °C

実験手順

16-Hexadecanolide (5.0 g, 0.02 mol) was added to a mixture of HI (30 g) and acetic acid (20 g). The mixture was heated to 100° C. overnight. After cooling it was poured into a cold sodium thiosulphate solution (150 mL, 10%) and extracted using CH2Cl2. The combined organic extracts were dried (MgSO4) and evaporated to give a white solid. The crude product was recrystallised from diethyl ether. Yield: 4.8 g (64%)

後処理

  1. temperatureAfter cooling it
  2. extractionextracted
  3. dry with materialThe combined organic extracts were dried (MgSO4)
  4. customevaporated
  5. customto give a white solid
  6. customThe crude product was recrystallised from diethyl ether

出典と根拠

ORDレコード
ord-5e69fe56e7e042fd9f6eb6361228f83f
出典データセット
uspto-grants-2002_09
特許番号
US06447656B1

関連ノート

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