Hydrochloric Acid → 16-Mercaptohexadecanoic acid

HRID 1279135

反応式

HRID 1279135 の反応式
I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].NC(N)=[S:22].[OH-].[Na+].Cl>C(O)C>[SH:22][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4111116-Iodohexadecanoic acidHCID 2723790Thiourea

生成物 1

HCID 352258516-Mercaptohexadecanoic acid収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 16-iodohexadecanoic acid (6) (4.0 g, 10.4 mmol) and thiourea (0.88 g, 1.1 equiv.) in ethanol (100 mL) was refluxed overnight under N2 atmosphere. The solution was cooled to room temperature. Sodium hydroxide (1.0 g in 10 mL of water) wad added and the mixture was further heated for 2 hr. After cooling to room temperature 1N HCl was added and the product was extracted using CH2Cl2. The organic extract was dried and evaporated to give a white solid Yield: 2.1 g (69%)

後処理

  1. temperaturewas refluxed overnight under N2 atmosphere
  2. temperaturethe mixture was further heated for 2 hr
  3. additionwas added
  4. extractionthe product was extracted
  5. extractionThe organic extract
  6. customwas dried
  7. customevaporated

出典と根拠

ORDレコード
ord-48dae631f1574782807114973786c7b2
出典データセット
uspto-grants-2002_09
特許番号
US06447656B1

関連ノート

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