反応式
F[C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([B:8]([OH:10])[OH:9])[CH:7]=1.BrC1C=[C:18]([O:20]C)C=CC=1OC.[Li]CCCC.COB(OC)OC>>[CH3:12][O:11][C:5]1[CH:4]=[CH:3][C:2]([O:20][CH3:18])=[CH:7][C:6]=1[B:8]([OH:10])[OH:9]参加物
5
実験手順
This compound was prepared in a manner similar to that of 5-Fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 1-bromo-2,5-dimethoxybenzene (2.00 mL, 13.3 mmol), n-BuLi (2.5 M in hexanes; 5.34 mL, 13.3 mmol), and trimethylborate (4.5 mL, 40 mmol) to afford 2.43 g (99%) of 2,5-dimethoxyphenylboronic acid which was used without further purification.
出典と根拠
- ORDレコード
- ord-751b4c79d692484790fe287aa70cc713
- 出典データセット
- uspto-grants-2002_09
- 特許番号
- US06448405B1
関連ノート
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