Sodium Hydroxide → HCID 16727476、化合物

HRID 1280101ノート

反応式

HRID 1280101 の反応式
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([NH:18][NH2:19])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:20]2[CH:24]=[CH:23][O:22][CH:21]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C[O:26][C:27](=[O:37])[C:28]1[CH:33]=[CH:32][C:31]([C:34](Cl)=[O:35])=[CH:30][CH:29]=1.CCN(C(C)C)C(C)C.[OH-].[Na+]>CN(C=O)C.CC(O)=O>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([NH:18][NH:19][C:34]([C:31]4[CH:32]=[CH:33][C:28]([C:27]([OH:37])=[O:26])=[CH:29][CH:30]=4)=[O:35])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:20]2[CH:24]=[CH:23][O:22][CH:21]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

7

反応物 4

HCID 14798Sodium HydroxideHCID 81531DiisopropylethylamineHCID 81850Methyl 4-(chlorocarbonyl)benzoateHCID 233781581H-Benzimidazole-5-carboxylic acid, 1-cyclohexyl-2-(3-furanyl)-, hydrazide

生成物 1

HCID 16727476HCID 16727476、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6228Dimethylformamide溶媒

実験手順

1-Cyclohexyl-2-furan-3-yl-1H-benzoimidazole-5-carboxylic acid hydrazide (0.022 g, 0.068 mmol) and methyl-4-chlorocarbonylbenzoate (0.013 g, 0.068 mmol) were stirred in DMF (1 mL) in the presence of DIEA (0.018 g, 0.14 mmol) for 2 h. An aqueous solution of NaOH (2.5 N, 0.22 mL, 0.55 mmol) was then added and the mixture was stirred for 2 h at room temperature. The reaction mixture was acidified by the addition of AcOH and purified by reversed phase C18 preparative HPLC to give the title compound of example 143.

後処理

  1. custompurified by reversed phase C18 preparative HPLC

出典と根拠

ORDレコード
ord-b185259328b046feb2d4c0abbdc7b923
出典データセット
uspto-grants-2002_09
特許番号
US06448281B1

反応ノート

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