N-(2-phenyl-phenylmethyl)-phthalimide → 1-Biphenyl-2-ylmethanamine

HRID 1280819

反応式

HRID 1280819 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:13][N:14]2C(=O)C3=CC=CC=C3C2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O.NN>[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:13][NH2:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 18426122N-(2-phenyl-phenylmethyl)-phthalimide

生成物 1

HCID 2633661-Biphenyl-2-ylmethanamine収率 78.9%

試薬・触媒・溶媒 1

HCID 24654Hydrazine hydrate (1:1)溶媒

実験手順

N-(2-Phenyl-phenylmethyl)-phthalimide (6.5 g) in 25 cc of hydrazine hydrate were stirred at room temperature overnight. Ice water was added and the solid separated by filtration. The filtrate was salted out with brine and extracted with ethyl acetate. The ethyl acetate extract was washed with water, dried over magnesium sulfate, filtered and concentrated to dryness to afford 3 g of subtitled product as an oil.

後処理

  1. customthe solid separated by filtration
  2. extractionextracted with ethyl acetate
  3. extractionThe ethyl acetate extract
  4. washwas washed with water
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-92513ac2ba0f4915b383c24c79517d71
出典データセット
uspto-grants-2002_09
特許番号
US06451839B1

関連ノート

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