Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine
反応式
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6]Br.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>CC(CC)=O>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1参加物
6
実験手順
To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.
後処理
- temperatureThe mixture is refluxed for 24 hours
- temperatureAfter cooling
- filtrationthe mixture is filtered
- washwashed with 3×300 ml benzene
- customAfter evaporation of the benzene
- distillationthe piperazine derivative is distilled
- customb.p. 25 mm Hg=190° C.
出典と根拠
- ORDレコード
- ord-81ef5e212bdb488faab82b396a9fc6ad
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04259334
反応ノート
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