Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

HRID 128205

反応式

HRID 128205 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6]Br.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>CC(CC)=O>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

参加物

6

反応物 4

HCID 4837PiperazineHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 24522082-(2-Bromoethoxy)-1,3-dimethylbenzene

生成物 1

HCID 234686521-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.

後処理

  1. temperatureThe mixture is refluxed for 24 hours
  2. temperatureAfter cooling
  3. filtrationthe mixture is filtered
  4. washwashed with 3×300 ml benzene
  5. customAfter evaporation of the benzene
  6. distillationthe piperazine derivative is distilled
  7. customb.p. 25 mm Hg=190° C.

出典と根拠

ORDレコード
ord-81ef5e212bdb488faab82b396a9fc6ad
出典データセット
uspto-grants-1981_03
特許番号
US04259334

関連ノート

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