Thionyl Chloride → N-(4-(1-chloroethyl)phenylmethyl)acetamide
反応式
O[CH:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][C:12](=[O:14])[CH3:13])=[CH:6][CH:5]=1)[CH3:3].S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[Cl:17][CH:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][C:12](=[O:14])[CH3:13])=[CH:6][CH:5]=1)[CH3:3]参加物
4
実験手順
A solution of N-{[4-(1-hydroxyethyl)phenyl]methyl}acetamide (5.7 g) and thionyl chloride (2.6 ml) in chloroform (50 ml) was refluxed under heating for 1.5 hr. The solvent was evaporated to give a brown oil (6.7 g). The obtained brown oil was purified by silica gel column chromatography (developing solvent; chloroform:methanol=20:1) to give the title compound (5.5 g) as a pale-brown oil.
後処理
- temperatureunder heating for 1.5 hr
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-587b739f98f14db3a7b89b05d50dd930
- 出典データセット
- uspto-grants-2002_09
- 特許番号
- US06455528B1
反応ノート
読み込み中…