Dimethyl Sulfoxide → 2-Cyano-2-(2-phenoxyphenyl)hexyl bromide

HRID 128223ノート

反応式

HRID 128223 の反応式
[O:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]#[N:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:21][CH2:22]Br.CS(C)=O.[OH-].[Na+]>O>[C:15]([C:14]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[O:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:22][Br:21])#[N:16]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 3024DibromomethaneHCID 14798Sodium HydroxideHCID 197756142-(2-Phenoxyphenyl)hexanenitrile

生成物 1

HCID 234689402-Cyano-2-(2-phenoxyphenyl)hexyl bromide収率 82.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a three-necked 300 ml round bottom flask are charged 10 g (0.038 mole) of 2-(2-phenoxyphenyl)hexanenitrile, 6.6 g (0.038 mole) of dibromomethane and 50 ml of dimethyl sulfoxide. To this mixture with stirring is added 3.2 g (0.04 mole) of 50% sodium hydroxide solution dropwise. Reaction mixture is heated to give 60° for two hours and then poured into water and extracted with hexane. Combined hexane extracts are washed with water and dried over MgSO4. Solvent is evaporated under vacuum to give 11.2 g of product.

後処理

  1. customReaction mixture
  2. temperatureis heated
  3. customto give 60° for two hours
  4. extractionextracted with hexane
  5. washCombined hexane extracts are washed with water
  6. dry with materialdried over MgSO4
  7. customSolvent is evaporated under vacuum

出典と根拠

ORDレコード
ord-a04fc54f54674e53baa7f7023a3030e8
出典データセット
uspto-grants-1981_03
特許番号
US04259339

反応ノート

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