Formaldehyde → HCID 23469001、化合物

HRID 128239ノート

反応式

HRID 128239 の反応式
Cl.[CH3:2][NH:3][CH3:4].[CH:5]1([N:11]2[CH:15]=[CH:14][CH:13]=[CH:12]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[CH2:16]=O>C(O)C.O>[CH:5]1([N:11]2[CH:15]=[CH:14][CH:13]=[C:12]2[CH2:2][N:3]([CH3:16])[CH3:4])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1

参加物

6

反応物 3

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 138996051-Cyclohexyl-1H-pyrrole

生成物 1

HCID 23469001HCID 23469001、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of dimethylamine hydrochloride (3.76 g) in 40% aqueous formaldehyde (3.5 ml) was added over 30 minutes to a stirred solution of 1-cyclohexylpyrrole in ethanol (25 ml) and the resulting solution was stirred at room temperature for 18 hours. Evaporation of the solution gave a solid which was dissolved in water. The solution was extracted with ether and then basified to pH 9-10 with 1 N sodium hydroxide solution. The resulting oil was extracted with ether (3×50 ml) and the combined ethereal extracts were washed with water and dried (MgSO4). Evaporation of the ether gave an oil which was chromatographed on silica gel. Elution with chloroform gave 1-cyclohexyl-2-(dimethylaminomethyl)pyrrole (5.0 g) as an oil.

後処理

  1. customEvaporation of the solution
  2. customgave a solid which
  3. extractionThe solution was extracted with ether
  4. extractionThe resulting oil was extracted with ether (3×50 ml)
  5. washthe combined ethereal extracts were washed with water
  6. dry with materialdried (MgSO4)
  7. customEvaporation of the ether
  8. customgave an oil which
  9. customwas chromatographed on silica gel
  10. washElution with chloroform

出典と根拠

ORDレコード
ord-ae019736782a44238c28b9cc71766876
出典データセット
uspto-grants-1981_03
特許番号
US04259345

反応ノート

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