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Benzoyl chloride → 1-Benzoylimidazolidin-2-one

HRID 1283018
ノート
印刷プレビュー

反応式

HRID 1283018 の反応式
[NH:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6].O1CCCC1.[C:12](Cl)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[C:12]([N:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 7412Benzoyl chlorideHCID 8028Tetrahydrofuran2 回HCID 84532-ImidazolidinoneHCID 516892Sodium Bicarbonate

生成物 1

HCID 5696651-Benzoylimidazolidin-2-one

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
10 °C

実験手順

8.6 parts by weight of imidazolid-2-one in 100 parts by volume of dry tetrahydrofurane were treated with 15.5 parts by weight of benzoyl chloride in 30 parts by volume of tetrahydrofurane over the course of 15 minutes, at 5°-10°C, and the mixture was subsequently stirred for 3 hours at 10°C. The solvent was stripped off, the residue was shaken with a mixture of chloroform and aqueous NaHCO3 solution for 15 minutes, the chloroform was separated off, the water was again extracted with chloroform and the combined organic phases were washed with water, dried over MgSO4 and evaporated. The residue was recrystallized from ethyl acetate/ether.

後処理

  1. customthe chloroform was separated off
  2. extractionthe water was again extracted with chloroform
  3. washthe combined organic phases were washed with water
  4. dry with materialdried over MgSO4
  5. customevaporated
  6. customThe residue was recrystallized from ethyl acetate/ether

出典と根拠

ORDレコード
ord-49382d9603cc462e8a52570178f2ea8d
出典データセット
uspto-grants-1976_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US03974141

反応ノート

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このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート