Methyl iodide → HCID 15581183、化合物

反応式

[Na].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[CH2:8][C:9]3[CH:15]=[C:14]([CH:16]([C:20]#[N:21])[C:17]([CH3:19])=[O:18])[CH:13]=[CH:12][C:10]=3[O:11][C:3]=12.[CH3:22]I>CN(C)C=O>[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[CH2:8][C:9]3[CH:15]=[C:14]([C:16]([C:20]#[N:21])([CH3:22])[C:17](=[O:18])[CH3:19])[CH:13]=[CH:12][C:10]=3[O:11][C:3]=12

参加物

実験手順

2.9 g of sodium salt of 1-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)-1-cyano-acetone is dissolved in 15 ml of dried dimethylformamide, 1.6 g of methyl iodide is added to the solution with stirring, and the mixture is stirred at room temperature for 1.5 hours. The reaction mixture is concentrated, and water is added to the oily residue. The crystalline precipitate is filtered off and recrystallized from ethanol to give 2.2 g of 3-(5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)-3-cyano-2-butanone as white needles melting at 163.5°-164.5°C.