Chloroacetyl chloride → Thiophene-3,4-dicarboxylic acid
反応式
ClCC(Cl)=[O:4].[S:6]1[CH:10]=[C:9]2[C:11]([O:13][C:14](=[O:15])[C:8]2=[CH:7]1)=[O:12]>>[S:6]1[CH:10]=[C:9]([C:11]([OH:4])=[O:12])[C:8]([C:14]([OH:13])=[O:15])=[CH:7]1参加物
3
実験手順
A 25.5 g. portion of 3,4-thiophenedicarboxylic acid {prepared by the method of Kornfeld and Jones [J. Org. Chem., 19, 1671 (1954)]} is suspended in 50 ml. of chloroacetyl chloride and is heated at reflux for 5.5 hours. Excess chloroacetyl chloride is distilled under reduced pressure. The residue is poured into 100 ml. of water and the resulting crystals are collected to yield 16.1 g. of 3,4-thiophenedicarboxylic anhydride.
後処理
- temperatureat reflux for 5.5 hours
- distillationExcess chloroacetyl chloride is distilled under reduced pressure
- additionThe residue is poured into 100 ml
- customof water and the resulting crystals are collected
- customto yield 16.1 g
出典と根拠
- ORDレコード
- ord-cdd40e584b9e4651ba74e24770d441ee
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04259476
反応ノート
読み込み中…