Chloroacetyl chloride → Thiophene-3,4-dicarboxylic acid

HRID 128352

反応式

HRID 128352 の反応式
ClCC(Cl)=[O:4].[S:6]1[CH:10]=[C:9]2[C:11]([O:13][C:14](=[O:15])[C:8]2=[CH:7]1)=[O:12]>>[S:6]1[CH:10]=[C:9]([C:11]([OH:4])=[O:12])[C:8]([C:14]([OH:13])=[O:15])=[CH:7]1

参加物

3

反応物 2

HCID 6577Chloroacetyl chlorideHCID 3156081H,3H-Thieno[3,4-c]furan-1,3-dione

生成物 1

HCID 255853Thiophene-3,4-dicarboxylic acid

実験手順

A 25.5 g. portion of 3,4-thiophenedicarboxylic acid {prepared by the method of Kornfeld and Jones [J. Org. Chem., 19, 1671 (1954)]} is suspended in 50 ml. of chloroacetyl chloride and is heated at reflux for 5.5 hours. Excess chloroacetyl chloride is distilled under reduced pressure. The residue is poured into 100 ml. of water and the resulting crystals are collected to yield 16.1 g. of 3,4-thiophenedicarboxylic anhydride.

後処理

  1. temperatureat reflux for 5.5 hours
  2. distillationExcess chloroacetyl chloride is distilled under reduced pressure
  3. additionThe residue is poured into 100 ml
  4. customof water and the resulting crystals are collected
  5. customto yield 16.1 g

出典と根拠

ORDレコード
ord-cdd40e584b9e4651ba74e24770d441ee
出典データセット
uspto-grants-1981_03
特許番号
US04259476

関連ノート

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