Hydrochloric Acid → 3-Chloro-4-methoxybenzoyl chloride

HRID 1283641

反応式

HRID 1283641 の反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([Cl:12])[CH:5]=1.[OH-].[Na+].[ClH:16]>O>[Cl:12][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[O:10][CH3:11])[C:3]([Cl:16])=[O:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 123469Methyl 3-chloro-p-anisate

生成物 1

HCID 47692993-Chloro-4-methoxybenzoyl chloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 10.4 g. (0.052 mol.) of 3-chloro-4-methoxybenzoic acid methyl ester and 3.5 g. (0.09 mol.) of sodium hydroxide in 150 ml. of water was refluxed for two hours. The reaction mixture was cooled and acidified with 10% aqueous hydrochloric acid to precipitate 3-chloro-4-methoxybenzoic acid, m.p. 199°-202°. The acid was refluxed with thionyl chloride as described in the procedure of Example 9 to give 3-chloro-4-methoxybenzoic acid chloride, m.p. 55°-57°.

後処理

  1. additionA mixture of 10.4 g
  2. temperatureThe reaction mixture was cooled
  3. customto precipitate 3-chloro-4-methoxybenzoic acid, m.p. 199°-202°
  4. temperatureThe acid was refluxed with thionyl chloride

出典と根拠

ORDレコード
ord-3d84c3f678a24b7e9b92c4cbcf018d63
出典データセット
uspto-grants-1976_08
特許番号
US03975537

関連ノート

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