Triethylamine → N-((Phenylmethoxy)carbonyl)-L-phenylalanine ethyl ester

HRID 1283773

反応式

HRID 1283773 の反応式
[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:20]([OH:22])=[O:21])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23](OC(ON=C(C#N)C(N)=O)=O)[CH3:24].C(N(CC)CC)C>C(OCC)(=O)C>[CH2:23]([O:21][C:20](=[O:22])[C@H:12]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH3:24]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 70878Benzyloxycarbonyl-L-phenylalanineHCID 545656502-Ethoxycarbonyloxyimino-2-cyanoacetic acid amide

生成物 1

HCID 34309N-((Phenylmethoxy)carbonyl)-L-phenylalanine ethyl ester収率 103.6%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a suspension of N-benzyloxycarbonyl-L-phenylalanine (1.5 g) and 2-ethoxycarbonyloxyimino-2-cyanoacetic acid amide (0.95 g) in ethyl acetate (20 ml), a solution of triethylamine (0.7 ml) in ethyl acetate (5 ml) is dropwise added at -10°C, and the resulting mixture is stirred at the same temperature for 20 minutes and then at room temperature for 2 hours. After allowed to stand over night, the reaction mixture is treated as in Example A to give N-benzyloxycarbonyl-L-phenylalanine ethyl ester (1.7 g) as an oil.

後処理

  1. waitat room temperature for 2 hours
  2. waitto stand over night
  3. additionthe reaction mixture is treated as in Example A

出典と根拠

ORDレコード
ord-47463f5bc2a5497dae441e3e30c41c99
出典データセット
uspto-grants-1976_08
特許番号
US03976635

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