Sodium Hydroxide → 4-Amino-3-hydrazino pyridazine

HRID 1284326ノート

反応式

HRID 1284326 の反応式
[NH2:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[N:4][C:3]=1[NH:9][NH2:10].[OH-].[Na+].[H][H]>CO.[Pd]>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[N:4][C:3]=1[NH:9][NH2:10]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 2500056-Chloro-3-hydrazinylpyridazin-4-amineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 215154024-Amino-3-hydrazino pyridazine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回

実験手順

A solution of 4 g of 4-amino-6-chloro-3-hydrazinopyridazine in 240 ml. of methanol and 60 ml. of 0.5 N sodium hydroxide in methanol are charged into a Paar shaker. To this solutionn, 2 g. of 10% palladium on carbon catalyst is added. The Paar shaker is charged at room temperature with hydrogen to an initial pressure of 50 psi and shaken. After about 4 hours, the reaction mixture is filtered, the solvent evaporated, and the residue extracted with chloroform. The chloroform solution is evaporated to dryness, and the 4-amino-3-hydrazino pyridazine obtained is dissolved in methanol. Hydrogen chloride gas is bubbled in, and the 4-amino-3-hydrazinopyridazine dihydrochloride (m.p. 281°-283°C.) which precipitates is separated by filtration.

後処理

  1. filtrationthe reaction mixture is filtered
  2. customthe solvent evaporated
  3. extractionthe residue extracted with chloroform
  4. customThe chloroform solution is evaporated to dryness

出典と根拠

ORDレコード
ord-f3e8cc90fb3a4b08a555cf1c9408a0c8
出典データセット
uspto-grants-1976_08
特許番号
US03978057

反応ノート

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