Hydrochloric Acid → 4-Acetyl-4-pentylheptanedinitrile

HRID 1285033ノート

反応式

HRID 1285033 の反応式
[CH3:1][C:2](=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH-].[K+].CO.[C:14](#[N:17])[CH:15]=[CH2:16].Cl>C(O)(C)(C)C>[C:2]([C:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])([CH2:16][CH2:15][C:14]#[N:17])[CH2:16][CH2:15][C:14]#[N:17])(=[O:9])[CH3:1]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7855AcrylonitrileHCID 80932-OctanoneHCID 23689386Potassium hydroxide methanol

生成物 1

HCID 126597364-Acetyl-4-pentylheptanedinitrile

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒2 回

反応条件

温度
5 °C

実験手順

In a flask, 600 g of 2-octanone (CH3 (CH2)5COCH3), 500 g of tert-butanol ((CH3)3COH) and 30 g of a KOH/CH3OH solution were mixed and then stirred under ice-cooling. To the resulting solution was added dropwise a solution of 375 g of acrylonitrile (CH2 =CHCN) in 400 g of (CH3)3COH while maintaining the temperature at 5° C. or lower. After completion of the addition, the resulting solution was further stirred continuously for 1 hour, after which this reaction solution was made neutral by addition of dilute hydrochloric acid. The deposited salt was separated by filtration, and the residue was distilled under reduced pressure to obtain 3-acetyl-1,5-dicyano-3-pentylpentane.

後処理

  1. temperaturecooling
  2. additionAfter completion of the addition
  3. stirringthe resulting solution was further stirred continuously for 1 hour
  4. customThe deposited salt was separated by filtration
  5. distillationthe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-5076c0ff9d294d62af09070583187dd7
出典データセット
uspto-grants-1986_01
特許番号
US04564694

反応ノート

読み込み中…