Thionyl Chloride → 1-Chloro-2-methyl-6-phenoxy-hexane
反応式
S(Cl)([Cl:3])=O.O[CH2:6][CH:7]([CH3:19])[CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(Cl)(Cl)Cl.CN(C=O)C>[Cl:3][CH2:6][CH:7]([CH3:19])[CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
5
実験手順
A solution of 60 g of thionyl chloride in 50 ml of CHCl3 was added dropwise to 100 g of 1-Hydroxy-2-methyl-6-phenoxy-hexane in 200 ml of CHCl3 and 0.5 ml of DMF. The solution was refluxed until the development of the gas was finished and then poured onto ice. The aqueous phase was extracted twice with CHCl3 and the combined organic phases were washed with water and finally with a saturated NaHCO3 -solution, dried with MgSO4, evaporated and the residue was distilled off.
後処理
- temperatureThe solution was refluxed until the development of the gas
- additionpoured onto ice
- extractionThe aqueous phase was extracted twice with CHCl3
- washthe combined organic phases were washed with water and finally with a saturated NaHCO3 -solution
- dry with materialdried with MgSO4
- customevaporated
- distillationthe residue was distilled off
出典と根拠
- ORDレコード
- ord-0c447d406cfd4a7695fa61ca2c9da751
- 出典データセット
- uspto-grants-1976_10
- 特許番号
- US03984459
反応ノート
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