Hydrochloric Acid → (1-Oxo-2-ethyl-2-hydroxymethyl-6,7-dichloro-5-indanyloxy)acetic Acid

HRID 1287424ノート

反応式

HRID 1287424 の反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][CH:3]1[CH2:18][CH3:19].[OH-:20].[Na+].[CH2:22]=O.Cl>O>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][C:3]1([CH2:18][CH3:19])[CH2:22][OH:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 33794Acetic acid, 6,7-dichloro-2-ethyl-1-oxo-5-indanyloxy-

生成物 1

HCID 20358453(1-Oxo-2-ethyl-2-hydroxymethyl-6,7-dichloro-5-indanyloxy)acetic Acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of (1-oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetic acid (3.03 g., 0.01 mole) and sodium hydroxide (0.5 g., 0.0125 mole) in water (90 ml.) is added aqueous formaldehyde (1 ml., 0.012 mole). The resulting solution is stirred at 20°-25° C. for 41/2 days and acidified with hydrochloric acid. The tan powder which precipitates is recrystallized from ethanol-water affording 1.2 g. of (1-oxo-2-ethyl-2-hydroxymethyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 155°-157° C.

後処理

  1. customThe tan powder which precipitates
  2. customis recrystallized from ethanol-water affording 1.2 g

出典と根拠

ORDレコード
ord-448f27ef31614d08af0d4384921fa2d5
出典データセット
uspto-grants-1976_10
特許番号
US03984465

反応ノート

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