Carbon Dioxide → 2,4-Difluoro-3-methylbenzoic acid

温度

-50 °C

Into a flask equipped with stirrer, dropping funnel, carbon dioxide condenser and gas inlet tube are charged 100 g. (0.78 mole) of 2,4-difluoro-toluene and 500 ml. of dry tetrahydrofuran. The system is flushed with dry nitrogen and cooled (carbon dioxide-acetone bath) to an internal temperature of -50°C. A 585 ml. solution of 15% n-butyllithium (0.935 mole n-butyl-lithium) in hexane is added dropwise into a flask. The resulting dark red-purple solution is maintained at -50°C. for about one hour, and then poured onto a slurry of about 1000 g. of powdered carbon dioxide and about 100 ml. of diethyl ether. After standing for about 20 hours at room temperature the residue is treated with 250 ml. of 2N sodium hydroxide. The caustic layer is washed with toluene, acidified with concentrated HCl, and the white precipitate which forms is recrystallized from hot chloroform to give 2,6-difluoro-m-toluic acid; m.p. 139°-140°C.

1. customInto a flask equipped with stirrer
2. additionare charged 100 g
3. customThe system is flushed with dry nitrogen
4. temperatureThe resulting dark red-purple solution is maintained at -50°C. for about one hour
5. additionpoured onto a slurry of about 1000 g
6. additionthe residue is treated with 250 ml
7. washThe caustic layer is washed with toluene
8. customthe white precipitate which forms is recrystallized from hot chloroform

ORDレコード

ord-bbd8e98a44fd402a928ec14e0ad4ef75

出典データセット

uspto-grants-1976_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US03985799