4-Hydroxybenzaldehyde → p-(Octyloxy)benzaldehyde

HRID 128778

反応式

HRID 128778 の反応式
[H-].[Na+].[OH:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1.Br[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>CN(C)C=O>[CH2:13]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

参加物

5

反応物 3

HCID 1264-HydroxybenzaldehydeHCID 81401-BromooctaneHCID 24758Sodium hydride

生成物 1

HCID 90358p-(Octyloxy)benzaldehyde

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Sodium hydride (4.2 g of 60% dispersion in oil) is added to a solution of 4-hydroxybenzaldehyde (12.2 g) in dimethylformamide. The mixture is stirred for 30 min, and 1-bromooctane (18 ml) is added. The reaction mixture is stirred at 90° for five hours, cooled, and the solvent removed in vacuo. The residue is shaken with water, and extracted with three portions of hexane. The hexane extracts are dried, concentrated, and distilled in vacuo to provide 20.3 g of 4-octyloxybenzaldehyde.

後処理

  1. stirringThe reaction mixture is stirred at 90° for five hours
  2. temperaturecooled
  3. customthe solvent removed in vacuo
  4. stirringThe residue is shaken with water
  5. extractionextracted with three portions of hexane
  6. dry with materialThe hexane extracts are dried
  7. concentrationconcentrated
  8. distillationdistilled in vacuo

出典と根拠

ORDレコード
ord-9d34e36668c044eab835a9a616aded82
出典データセット
uspto-grants-1995_11
特許番号
US05464865

関連ノート

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