Formaldehyde → Methylglyoxal

HRID 1288662

反応式

HRID 1288662 の反応式
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].C=O.C(C(/C=C\C(O)=O)=O)C(CC(O)=O)=[O:25].ClC(Cl)(Cl)C(C1C=CC(Cl)=CC=1)C1C=CC(Cl)=CC=1>>[CH3:6][C:2]([CH:3]=[O:5])=[O:25].[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4]

参加物

6

反応物 4

HCID 712FormaldehydeHCID 30361-Chloro-4-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzeneHCID 124886GlutathioneHCID 52803934-Maleylacetoacetic acid

生成物 2

HCID 880MethylglyoxalHCID 124886Glutathione

実験手順

Glutathione functions as a co-enzyme for formaldehyde dehydrogenase, maleylacetoacetate isomerase, glyoxalase, prostaglandin endoperoxidase isomerases, and dichlorodiphenyltrichloroethane dehydrochlorinase and similar enzymes. In the glyoxalase reaction, the hemimercaptal formed nonenzymatically by reaction of methylglyoxal and glutathione (GSH) is converted by glyoxalase I to S-lactyl-Glutathione, which is split by glyoxalase II to D-lactate and Glutathione. In the formaldehyde dehydrogenase reaction, S-formyl Glutathione is formed (Glutathione+HCHO+NAD+) and hydrolyzed to formate and Glutathione.

後処理

  1. customIn the glyoxalase reaction

出典と根拠

ORDレコード
ord-20f240749d8c4433b23b4769c315dad3
出典データセット
uspto-grants-1998_05
特許番号
US05747329

関連ノート

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