Guanidine → HCID 15841104、化合物

HRID 1289214ノート

反応式

HRID 1289214 の反応式
[CH3:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([C:18]([F:21])([F:20])[F:19])=[CH:7][C:3]=1[C:4](O)=[O:5].CC1C=C(OC2C=CC=CC=2)C(Br)=CC=1C(OC)=O.FC(F)(F)C([O-])=O.[K+].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:61][C:62]([NH2:64])=[NH:63]>[I-].C[N+](C)(C)C.C1COCC1>[NH2:63][C:62]([NH2:64])=[N:61][C:4](=[O:5])[C:3]1[CH:7]=[C:8]([C:18]([F:21])([F:20])[F:19])[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][C:2]=1[CH3:1]

参加物

8

反応物 5

HCID 3520GuanidineHCID 682631,1'-CarbonyldiimidazoleHCID 15841102HCID 15841102、化合物HCID 15841103HCID 15841103、化合物HCID 23662811Potassium trifluoroacetate

生成物 1

HCID 15841104HCID 15841104、化合物

試薬・触媒・溶媒 2

HCID 6381Tetramethylammonium iodide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 0.5 g of 2-methyl-4-phenoxy5-trifluoromethylbenzoic acid [obtainable by reaction of methyl 2-methyl-4-phenoxy-5-bromobenzoate with potassium trifluoroacetate in the presence of Cul and tetramethylammonium iodide and subsequent hydrolysis] and 300 mg of carbonyldiimidazole in 15 ml of THF is stirred at room temperature for two hours and then added to 383 mg of guanidine. The mixture is stirred for a further two hours. After customary working up, N-diaminomethylene-2-methyl-4-phenoxy-5-trifluoromethylbenzamide is obtained.

後処理

  1. stirringThe mixture is stirred for a further two hours

出典と根拠

ORDレコード
ord-d6bba8111a0248c1b7b81e7ae27eeeac
出典データセット
uspto-grants-1998_05
特許番号
US05747539

反応ノート

読み込み中…