Deuterium Oxide → 3-[[5-[(Acetylhydroxyamino)methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid monosodium salt

HRID 1290382

反応式

HRID 1290382 の反応式
[Na+:1].[C:2]([N:5]([CH2:14][CH:15]1[O:19][CH2:18][CH:17]([S:20][C:21]2[CH:27]([CH3:28])[CH:26]3[N:23]([C:24](=[O:32])[CH:25]3[CH:29]([OH:31])[CH3:30])[C:22]=2[C:33]([O-:35])=[O:34])[CH2:16]1)[O:6]CC1C=CC=CC=1)(=[O:4])[CH3:3].[2H]O[2H]>[Pd]>[Na+:1].[C:2]([N:5]([CH2:14][CH:15]1[O:19][CH2:18][CH:17]([S:20][C:21]2[CH:27]([CH3:28])[CH:26]3[N:23]([C:24](=[O:32])[CH:25]3[CH:29]([OH:31])[CH3:30])[C:22]=2[C:33]([O-:35])=[O:34])[CH2:16]1)[OH:6])(=[O:4])[CH3:3]

参加物

4

反応物 2

HCID 24602Deuterium OxideHCID 1317198433-[[5-[[Acetyl(phenylmethoxy)amino]methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt

生成物 1

HCID 1317198453-[[5-[(Acetylhydroxyamino)methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid monosodium salt収率 84.9%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A mixture of 0.010 g of product from Example 75, 0.014 g of 10% palladium/carbon, and 1 ml of deuterium oxide is reduced in a Parr apparatus for 2 hours at 30 psi. The reaction solution is filtered and lyophilyzed to give 0.007 g of the desired product.

後処理

  1. filtrationThe reaction solution is filtered

出典と根拠

ORDレコード
ord-bf297251231b407198da1c6abc925434
出典データセット
uspto-grants-1998_05
特許番号
US05750735

関連ノート

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