Pyridine → N-(11-Carbomethoxyundecanoyl)-2-hydroxyaniline

HRID 1290717ノート

反応式

HRID 1290717 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].N1C=CC=CC=1.[C:15]([O:30][CH3:31])(=[O:29])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O-])=[O:27]>C(Cl)Cl>[C:15]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8])=[O:27])([O:30][CH3:31])=[O:29]

参加物

5

反応物 3

HCID 1049PyridineHCID 58012-AminophenolHCID 22672980Dodecanedioic acid, monomethyl ester

生成物 1

HCID 18795789N-(11-Carbomethoxyundecanoyl)-2-hydroxyaniline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

To a stirred near solution of 2-aminophenol (0.24 g, 2.2 mM) in anhydrous methylene chloride (25 mL) was added dry pyridine (0.66 mL) and the mixture cooled in an ice-water bath. A solution of (7) (0.525 g, 2.0 mM) in methylene chloride (2 mL) was added over 1 minute (2×1.5 mL methylene chloride rinses), and the mixture allowed to stir cold. After 30 minutes the bath was removed. After stirring overnight at ambient temperatures, the mixture was filtered, the solvents removed in vacuo, and the residue pumped to remove all traces of pyridine. The product, (44) was used as is in subsequent steps.

後処理

  1. temperaturethe mixture cooled in an ice-water bath
  2. customAfter 30 minutes the bath was removed
  3. stirringAfter stirring overnight at ambient temperatures
  4. filtrationthe mixture was filtered
  5. customthe solvents removed in vacuo
  6. customto remove all traces of pyridine

出典と根拠

ORDレコード
ord-d0b992ae376147b9b6b103338a8fd4ff
出典データセット
uspto-grants-1998_05
特許番号
US05753641

反応ノート

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