Water → 9,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

HRID 1290910ノート

反応式

HRID 1290910 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[C:11]2[NH:12][C:13](=O)[C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1.O.[OH-].[Na+]>O1CCCC1>[O:7]1[C:11]2[NH:12][CH2:13][C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 100133324,10-dihydro-9H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-9-oneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 218369669,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of 4 mmol of lithium aluminum hydride in 25 ml of anhydrous tetrahydrofuran is added 1 mmol of 9,10-dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-9-one. The mixture is refluxed for 12 hours and allowed to stand overnight. To the mixture is added dropwise 0.12 ml of water and then 6 ml of 1N sodium hydroxide. The mixture is extracted with ethyl acetate and the extract dried (Na2 SO4). The volatiles are removed in vacuo to give the desired product as a solid.

後処理

  1. temperatureThe mixture is refluxed for 12 hours
  2. extractionThe mixture is extracted with ethyl acetate
  3. customthe extract dried (Na2 SO4)
  4. customThe volatiles are removed in vacuo

出典と根拠

ORDレコード
ord-95b84746cdc94b6baa327238d729b3b7
出典データセット
uspto-grants-1998_05
特許番号
US05753648

反応ノート

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