Water → 1-Tosylpyrozole

HRID 1293150ノート

反応式

HRID 1293150 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[C:6]1([CH3:16])[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1.O>N1C=CC=CC=1>[C:6]1([CH3:16])[CH:11]=[CH:10][C:9]([S:12]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 1048PyrazoleHCID 73974-Toluenesulfonyl chloride

生成物 1

HCID 3207501-Tosylpyrozole収率 15.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
130 °C

実験手順

A suspension of pyrazole (1 g) and 4-toluenesulfonyl chloride (2.8 g) in pyridine (10 ml) was stirred at 130° C. for 1 hour. After the reaction mixture was cooled, water was added to the reaction mixture, resulting in a white suspension. The resultant suspension was filtered, and the obtained white solids were washed three times with water. Drying at room temperature under reduced pressure gave white solids (500 mg).

後処理

  1. temperatureAfter the reaction mixture was cooled
  2. customresulting in a white suspension
  3. filtrationThe resultant suspension was filtered
  4. washthe obtained white solids were washed three times with water
  5. customDrying at room temperature under reduced pressure

出典と根拠

ORDレコード
ord-27d2bf1fc6a949e3be428f9784d16fe0
出典データセット
uspto-grants-2007_07
特許番号
US07238720B2

反応ノート

読み込み中…