Benzenepropanoic acid → Methyl 3-phenylpropionate
反応式
[C:1]1([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[CH3:17]O>>[C:1]1([CH2:7][CH2:8][C:9]([O:11][CH3:17])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
A solution of 3-phenylpropionic acid (50 g, 0.33 mole) and conc. sulfuric acid (5 g) in methanol (220 ml) was refluxed for 1 hour with stirring, concentrated and poured into cold H2O. The mixture was extracted thrice with methylene chloride (75 ml), the organic layer was washed thrice with H2O (125 ml), dried over anhydrous MgSO4 and evaporated. The residual crude oil (54 g) was distilled under reduced pressure to give 51.5 g of methyl 3-phenylpropionate as a colorless oil having a boiling point of 94°-95° C./5 mmHg.
後処理
- concentrationconcentrated
- additionpoured into cold H2O
- extractionThe mixture was extracted thrice with methylene chloride (75 ml)
- washthe organic layer was washed thrice with H2O (125 ml)
- dry with materialdried over anhydrous MgSO4
- customevaporated
- distillationThe residual crude oil (54 g) was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-7856235b707843d0969564f945d077cb
- 出典データセット
- uspto-grants-1995_11
- 特許番号
- US05468589
反応ノート
読み込み中…