Lithium Hydroxide → Oxane-4-carboxylic acid
反応式
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]([O:9]C)=[O:8])[CH2:3][CH2:2]1.[Li+].[OH-]>C(O)C>[O:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1参加物
4
実験手順
Methyl tetrahydro-2H-pyran-4-carboxylate (270 g, 1.87 mol) was diluted in ethanol (2 L). A 1M aqueous LiOH solution (1870 ml, 1.87 mol) was added (slight exotherm) at RT and the reaction was stirred for 3 hrs. The reaction mixture was concentrated to ca. 1 L and acidified to pH 2 with 5M HCl solution. The aqueous solution was extracted with ethyl acetate (3×600 ml) and the organic layer was dried (MgSO4) and evaporated to dryness to give a white solid (230.3 g, 94%).
後処理
- concentrationThe reaction mixture was concentrated to ca. 1 L
- extractionThe aqueous solution was extracted with ethyl acetate (3×600 ml)
- dry with materialthe organic layer was dried (MgSO4)
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-76e9fb2770784b0a8abd2575d9391bec
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728035B2
反応ノート
読み込み中…