Hydrochloric Acid → HCID 68886942、化合物

HRID 1294353ノート

反応式

HRID 1294353 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:30][C:31]([O:33]C)=[O:32])[CH:5]=[CH:6][C:7]=1[S:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:21][C:22]=2[CH3:23])[CH:11]=1.[OH-].[Na+].O1CCCC1.Cl>O.CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:30][C:31]([OH:33])=[O:32])[CH:5]=[CH:6][C:7]=1[S:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[O:21][C:22]=2[CH3:23])[CH:11]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 68886240HCID 68886240、化合物

生成物 1

HCID 68886942HCID 68886942、化合物収率 94%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A mixture of methyl 2-[3-chloro-4-[3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzylthio]phenyl]acetate. (0.47 g), a 1N aqueous sodium hydroxide solution (3 mL), tetrahydrofuran (5 mL) and methanol (5 mL) was stirred at room temperature for 1 hr. The reaction mixture was poured into water and acidified with 1N hydrochloric acid. The precipitated solid was collected by filtration and dried with air to give crystals (0.43 g, yield 94%) of 2-[3-chloro-4-[3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzylthio]phenyl]acetic acid. Recrystallization from ethyl acetate-methanol gave colorless prism crystals. melting point: 150-151° C.

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. customdried with air

出典と根拠

ORDレコード
ord-d7f25dc9ad574e7abadf38d776622a5c
出典データセット
uspto-grants-2007_07
特許番号
US07238716B2

反応ノート

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